Uchiha: The Uchiha Clan (うちは一族, Uchiha Ichizoku) is one of the four noble clans of Konohagakure, and was also reputed to be the village's most powerful clan, producing shinobi that were exceptionally talented and battle-oriented. Members of this clan also possessed the renowned Sharingan. Together with the Senju clan, they founded Konohagakure. Since its demise, the clan has been reduced to a single nuclear family.
Namikaze: Not much is known about this clan except that it originates from Takigakure and it's most remarkable member was Minato Namikaze.
Sarutobi: The Sarutobi Clan (猿飛一族, Sarutobi Ichizoku) is an influential clan from Konohagakure. It has produced several renowned members who have held positions of high authority, including the Third Hokage; whose son, Asuma, held membership in the Twelve Guardian Ninja, while his other child served directly under the Hokage along with their spouse as Anbu. All known members have also been observed devotees of the Will of Fire.
Jikura: This clan is very secretive, so not much is known. But they are a strong clan within Sunagakure and have 3 formidable ranks. The Enji, Denii, and Kokei. They are known to be the sister clan to the Uchiha, as they are able to use Sharingan, but they mainly use Sand or Fire.
Uzumaki: The Uzumaki Clan (うずまき一族, Uzumaki Ichizoku) was a prominent clan in Uzushiogakure. They were distant blood relatives of the Senju clan and as such, both were on good terms; an alliance that extended onto their hidden villages — Konohagakure and Uzushiogakure. The shinobi of Konoha integrated Uzushiogakure's symbol onto their uniforms and flak jackets as well as on the shoulders of their uniforms as a sign of friendship and goodwill between the two villages, and continue to do so to this day in memory of their friendship even years after Uzushiogakure's destruction. Currently reside in Konohagakure, and has produced the Seventh Hokage.
Senju: The Senju Clan (千手一族, Senju Ichizoku) was a group of shinobi that were the strongest, feared and most respected clan above all other clans in the ninja world during the war-torn era before the founding of the hidden villages. Together with their rivals — and distant relatives through a common ancestor — the Uchiha clan, they are responsible for founding the first hidden village named Konohagakure and under their philosophy of the Will of Fire, they are responsible for making the village, and later the Ninja World, into what it is today. The clan has produced three of the seven Hokage of Konoha: the First, the Second, and the Fifth. The clan shared deep familial ties with the Uzumaki clan, and from this the Seventh Hokage is also an indirect member.